We further determined the expression levels of these 11 genes (primers are shown in Supplementary Table S1) in Huh7, PLC, and HepG2 cells with S100A4 overexpression (Fig. 4b, c, d), as well as HCC-LM3 and MHCC97-H cells with S100A4 knockdown (Fig. 4e, f). The gene discussed is S100A4; the disease is hepatocellular carcinoma.