Furthermore, the 5-year OS and TTR of HCC patients in the low-exosomal S100A4 group were 69.81% and 61.50%, respectively, which were much higher than those in the high-exosomal S100A4 group (26.67% and 26.05%, respectively; p < 0.001) (Fig. 6c, d). The gene discussed is S100A4; the disease is hepatocellular carcinoma.