Interestingly, Jiao et al. reported that S100A4 + stromal cells could maintain HCC stemness, which suggests a crosstalk between inflammation and stemness.36 Our study suggested exosomal S100A4 could play a role in S100A4 + cell subpopulation in the crosstalk with cancer stem cells. The gene discussed is S100A4; the disease is hepatocellular carcinoma.