As OTUD7B was upregulated in ERα-positive breast cancer patients and associated with the ERα protein level, we then analyzed its prognostic value in ERα-positive breast cancer from GES6532, and observed that high expression of OTUD7B was associated with poor prognosis of patients with ERα-positive breast cancer (Fig. 2J, K). The gene discussed is OTUD7B; the disease is breast cancer.