In this study, we revealed that a significant positive correlation between the expression of the collagen genes and the infiltration of the six immune cell types (B cells, CD8 + T cells, CD4 + T cells, macrophages, neutrophils, and dendritic cells) in LGGs, and a positive correlation between the expression of the collagen genes and the infiltration of dendritic cells in GBM. This evidence concerns the gene CD4 and glioblastoma.