The main immuno-suppressive factors associated with breast cancer include PD-L1, GM-CSF, CTLA4, SDF1, CXCL5, IDO, IL-4, IL-8, IL-10, IL-13, MIF, NOS2, PD1, COX2, VEGF and TGF-β. The gene discussed is CXCL12; the disease is breast carcinoma.