To identify methylation-driven genes related to OS of HCC patients, survival data of 329 HCC patients and 44 methylation-driven gene expression were integrated, and C5orf58, LCAT, ADH1B, RPS6KA6, SFN and ZDBF2 were identified with univariate Cox regression analysis. The gene discussed is RPS6KA6; the disease is hepatocellular carcinoma.