In fact, several commercially available DNA methylation-based biomarkers, including DNA methylation of APC (adenomatosis polyposis coli) and RASSF1 (ras association domain family member 1) as both diagnostic and prognostic biomarkers of prostate cancer and DNA methylation of SEPT9 (septin 9) as predictive biomarker of colorectal cancer, were not correlated with host gene expression [4]. This evidence concerns the gene RASSF1 and Familial prostate cancer.