Similar considerations emerge from the two pedigrees shown in Fig. 3: in both cases there was a history of TNBC, a tumor often associated with a BRCA mutation, especially at a younger age (the same patient carrying a BRCA1 mutation, the patient’s daughter for BRCA2 mutation); the BRCA1 mutation carrier had an aunt with PC, and none of the two patients had relatives with a history of ovarian cancer. Here, BRCA1 is linked to ovarian carcinoma.