Moreover, MMP9 has been found to play a causal role in amyloid β (Aβ)-induced cognitive impairment and neurotoxicity [10], as intracerebroventricular injection of Aβ induced cognitive deficits and MMP9 expression in the mouse hippocampus, while Aβ exposure caused neurotoxicity in cultured neurons. Here, MMP9 is linked to Cognitive impairment.