She had a history of invasive ductal carcinoma (estrogen receptor (ER)-positive, progesterone receptor (PgR)-positive, human epidermal growth factor receptor 2-negative, Ki-67 index: 10.6%) of the left breast measuring over 5 cm, with multiple bone metastases to the spine, sternum, and left ileum, diagnosed 3 years prior. The gene discussed is ESR1; the disease is invasive ductal breast carcinoma.