PPARA and kidney disorder: There are three major findings: (1) proteins involved in mitochondrial energy production were significantly increased in NEVKP compared with SCS; (2) these proteins are significantly repressed in kidney disease of diverse etiologies as assessed in six external datasets; (3) PPAR and RXR transcription factors were computationally predicted upstream regulators of our metabolic proteins, and our gene expression findings support their increased activity in NEVKP.