In a Japanese prospective study (n = 1,074), the association between CRP and IR was less evident among adults with normal BMI (β 0.93 95% CI 0.86; 1,00) than among those with overweight (β 1.28 95% CI 1.17; 1,41) or obesity (β 2.13 95% CI 1.98; 2.29) (p-valuefor interaction < 0.001) (18). The gene discussed is CRP; the disease is obesity due to melanocortin 4 receptor deficiency.