RSPO1 and cancer: Cancer organoids have been grown in rich conditions supplied with niche factors including EGF, WNT, R‐spondin and other factors, whereas, by the alternation of niche factors in the culture medium, functional selection of CRISPR‐induced oncogenic mutations becomes possible,13, 14 and different cancer subtypes can be grown for establishing cognate PDOs from a mixture of different cancer subtypes.29