BYL‐719 significantly reduced cell proliferation assessed by Ki67 index in both primary and metastatic sites (Fig 6H–J, Appendix Fig S13B, for validation of cohort size, see the value of the Power test in Dataset EV5), associated with decreased tumour grading and changes in tumour cell/stroma ratios (Appendix Fig S14). The gene discussed is MKI67; the disease is neoplasm.