TNF and neoplasm: TNFα was previously found to promote transition from micro‐ to macro‐metastasis as BM‐derived EPCs are known to be critical regulators of the angiogenic switch in progression of micro‐metastasis to lethal macro‐metastasis (Gao et al,2008), and tumour‐derived TNF signalling had been linked in vivo to differentiation of myeloid progenitor cells to “byphenotypic” myeloid/ECs (Li et al,2009).