CD4 and neoplasm: BYL‐719 did not modify the overall F4/80+ macrophage count (Fig 7H and I), but significantly prevented their differentiation into pro‐tumourigenic CD206+ macrophages (tumour‐associated inflammatory macrophages) in tumour‐adjacent tissues (Fig 6H and J), with no significant difference in CD4+ and CD8+ infiltration (Appendix Fig S18).