We found that the genetic inactivation of PI3Kα in pancreatic cancer cells led to an altered cytokine secretion pattern in vitro (a panel of 16 cytokines were tested), with decreased levels of IL‐3 in two mutant Kras pancreatic cancer cell lines partly lacking PI3Kα activity (genetic inactivation) compared to three mutant Kras pancreatic cancer cell lines, including R211 cells (Fig 7E, Appendix Fig S17). Here, KRAS is linked to pancreatic neoplasm.