Previous study reported that tumor-infiltrating macrophages had a very strong direct correlation with frequency of tumor cell apoptosis (P < .0001) and degree of CD8 T cells (P = .0004).[15] Thus, tumor-infiltrating CD8 T cells were reported to be associated with a favorable survivals.[16] However, our study revealed that high abundance of CD8 T cells was a risk factor for overall survival (P = .049). This evidence concerns the gene CD8A and neoplasm.