ESR2 and metastatic malignant neoplasm in the lymph nodes: Of clinical relevance, ERα66 expression is associated with diffuse type GC, shorter DFS, or poor OS,[8,17,20,21] whereas ERα36 expression is correlated with lymph node metastasis in clinical samples.[22] Five different isoforms, ERβ1- ERβ5, have been identified for ERβ.