In recent years, many basic studies have also shown that acupuncture may improve the cognitive function of patients by improving the abnormal state of the cholinesterase system, regulating the synaptic plasticity of the hippocampus, and alleviating the inflammatory response of the central system.[21,22,23] This systematic review will evaluate the efficacy and safety of acupuncture in the treatment of T2DM with cognitive impairment. Here, BCHE is linked to type 2 diabetes mellitus.