A previous study showed that certain miRNA expression could decrease PD-L1 expression in patients with COAD.[45] In addition, Several studies also have revealed that miRNAs could decrease PD-L1 expression by binding to 3′-untranslated region of PD-L1, suggesting that miRNAs were negatively related with PD-L1 expression.[46–48] Moreover, miRNAs regulate PD-L1 expression and have potential therapeutic uses. This evidence concerns the gene CD274 and colon adenocarcinoma.