KCNK16 and type 2 diabetes mellitus: The KCNK16-containing locus is strongly associated with T2DM in multiple genome-wide association studies, including populations of differing ethnicities (17, 18, 26–28), with strongest association (P < 2 × 10–8) observed with the common nonsynonymous polymorphism rs1535500 (minor allele frequency [MAF] = 0.41, gnomAD database, subjects of non-Finnish European descent).