However, that association is observed with a common variant and T2DM in the same gene (KCNK16) in which we have identified a rare variant associated with MODY indicates that the encoded protein (i.e., TALK-1) is not functionally redundant, and raises the possibility of TALK-1 as a therapeutic target for T2DM. This evidence concerns the gene KCNK16 and type 2 diabetes mellitus.