KCNK16 and MODY: Here, we have used exome sequencing to identify the first family of whom we are aware with MODY due to a mutation in KCNK16. The Leu114Pro substitution in TALK-1 affects the K+ selectivity filter, causing a profound increase in K+ current, altering β cell Ca2+ flux, and decreasing GSIS in both human and mouse islet cells.