HMGCR and acute respiratory distress syndrome: Before COVID-19 era in a randomized placebo-controlled trial of unselected acute respiratory distress syndrome (ARDS) patients [Hydroxymethylglutaryl-CoA Reductase Inhibition with Simvastatin in Acute Lung Injury to Reduce Pulmonary Dysfunction-2 (HARP-2) Study], simvastatin started acutely was safe but did not affect prognosis [29].