ATXN3 and autosomal dominant cerebellar ataxia: In addition to drugs that target neuronal signalling in SCA, compounds stimulating autophagy or proteasome activity, such as rapamycin and Chinese herbal medicine extract NH037, exhibited an increased breakdown of expanded ATXN3 and a reduction of cytotoxicity and oxidative stress in SCA3 hiPSC-derived neurons [21, 73].