This may reflect how some gene-defined epilepsies are relatively similar early in the disease but evolve with variable types of seizures and outcomes, for example SCN1A-related epilepsies, which include Dravet syndrome and Febrile Seizures plus [17–19, 22]. The gene discussed is SCN1A; the disease is encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.