MAPK3 and Other metabolic disease: Furthermore, IPA showed that differentially expressed IF vs. CR genes converged on Erk1/2 as a central node in the top scoring interaction network involving processes such as “metabolic disease,” “cell death and survival,” and “behavior.” These transcriptional profiles suggest that genes modulated by IF are linked to an enhanced stress response and synaptic plasticity when compared to the CR and AL gene signatures.