ABI1 and colorectal carcinoma: Although clinical and experimental studies have shown that ABI1 plays an oncogenic role in CRC, high expression or low/high phosphorylation can induce the formation of lamellar pseudopodia and the degradation of extracellular matrix in CRC cells, thus promoting the clinical metastasis of CRC8,25–27,38, these studies have not included the roles of ABI1-TSVs.To date, research on the role of ABI1 in CRC has mainly focused on the establishment of clinical correlations and the analysis of cell phenotypes in vitro, and had no evidence of animal phenotypes in vivo8,25–27,38.