The binding of ABI1 and EPS8 could not only affect the localization and/or activity of actin nucleation, regulate the reconstruction of the actin cytoskeleton, and promote the assembly of filopodium structure and actin filaments of human breast cancer cells and mouse melanoma cells22, also seal the hook end of EPS8, promote actin capping, and directly induce F-actin-rich structure formation60. Here, ABI1 is linked to melanoma.