Immunohistochemical analysis of resected lung tissues demonstrated that the expression level of cleaved caspase-3, a marker for cells undergoing apoptosis in the caspase-dependent pathway, increased in PMCs on the visceral pleura from BHDS lung tissues compared with those from PSP lung tissues (Fig. 4E). The gene discussed is CASP3; the disease is supranuclear palsy, progressive, 1.