FLCN and supranuclear palsy, progressive, 1: When PMCs were stimulated with 1 mM AICAR, no increase of E-cadherin expression was found in BHDS-PMCs whereas the E-cadherin expression in PSP-PMCs significantly decreased at 24 h (Fig. 6A,B, right), suggesting that AICAR might be harmful to FLCN-preserved PSP-PMCs.