However, there is a paucity of experimental evidence on the overexpression of ABC superfamily transporters in LCSCs, which can be phenotypically defined as the cells expressing both EpCAM and CD133 (EPCAM+–CD133+) in Huh7 and PLC/PRF/5 human HCC cells21–27. The gene discussed is EPCAM; the disease is hepatocellular carcinoma.