Importantly, other PPIs have been shown to be critical for ID activity in the stem cell character of other tumors: ID2, for example, facilitates stemness in glioma by its association with the VHL complex and antagonism of the ubiquitin-mediated proteolysis of Hif2α75, so determining the effects of AGX51 on this pathway will be of great interest. Here, VHL is linked to central nervous system cancer.