The recurred mutations presented in Fig. 1d revealed the oncogenic drivers of NPC, such as TP53 (mutational frequency at 8.0%), CYLD (10.2%), KMT2C (5.7%), NOTCH2 (6.8%), NFKBIA (4.5%), FBXW7 (4.5%), ARID1A (2.3%), PTEN (2.3%), and BAP1(2.3%). This evidence concerns the gene NOTCH2 and nasopharyngeal carcinoma.