DNMT1 and infection: Furthermore, given the interaction between DNMT1 and ORF8 at the protein level, SAH could potentially work against SARS-CoV-2 infection, not only by inhibiting the methyltransferase activity of NSP16–NSP10 but also by directly modulating the activity of the key host proteins involved in the transcriptional response to infection or by interfering with the interactions observed between ORF8 and DNMT1.