Besides gene essentiality, nine members of the PI3K/AKT/mTOR (PAM) signaling pathway (RICTOR, SEH1L, HRAS, WDR59, ATP6V1H, RHEB, TTI1, MIOS, and GRB2) were identified, suggesting a prominent role for this pathway in promoting TNBC tumor growth. This evidence concerns the gene GRB2 and neoplasm.