PPDPF and steatosis: Compared with AAV8-con, AAV8-mediated reintroduction of PPDPF reduced body weight (Supplementary. 7d), liver weight (Supplementary Fig. 7e), liver TG (Fig. 6e), liver NEFA (Fig. 6f), lipid droplet accumulation (Fig. 6g), and the mRNA level of lipogenic genes (Supplementary Fig. 7f) of PPDPF-LKO mice after 3 months of HFD consumption, while AAV8-TBG-PPDPF mut could not alleviate HFD-induced steatosis (Fig. 6e–g, Supplementary Fig. 7d–f).