MTOR and metabolic dysfunction-associated steatotic liver disease: In sum, these findings revealed that reintroduction of PPDPF hindered HFD-induced NAFLD development in PPDPF-LKO mice, while PPDPF mut lost the rescue effect, indicating that the interaction between PPDPF and Raptor was important for the regulation of mTOR signaling and lipid metabolism by PPDPF.