CD8A and infection: The T-cell compartment overall was not affected by rDEN2Δ30 infection (Fig. 4e), though in the CD8+ T-cell compartment, cells of the effector memory re-expressing CD45RA (TEMRA) and central memory (TCM) phenotypes were found to be significantly regulated by infection, with weaker effects on cytotoxic, effector memory (TEM) and naive CD8+ T cells (Fig. 4f).