To further understand the role of CCN4, we employed the Gene Expression Profiling Interactive Analysis (GEPIA) server and conducted genomic data analysis using the TCGA and Genotype-Tissue Expression (GTEx) databases.26 The level of CCN4 transcripts was positively correlated with Runx2 and TGFβ in tumor tissues from patients with breast cancer (Fig. 6e). This evidence concerns the gene RUNX2 and breast carcinoma.