To further understand the role of CCN4, we employed the Gene Expression Profiling Interactive Analysis (GEPIA) server and conducted genomic data analysis using the TCGA and Genotype-Tissue Expression (GTEx) databases.26 The level of CCN4 transcripts was positively correlated with Runx2 and TGFβ in tumor tissues from patients with breast cancer (Fig. 6e). The gene discussed is RUNX2; the disease is breast cancer.