Lrp5 is a coreceptor of Wnt signaling and is known to play a crucial role in the mechanotransduction of bone22 and an undesirable role in tumor progression.32 The reduction in Lrp5 via dopaminergic signaling inhibited CCN4, followed by the downregulation of MMP9, Runx2, Snail, and TGFβ.19 CCN4 is known to stimulate tumor growth via Wnt signaling, and its downregulation through loading-driven inhibition of Lrp5 is essential for tumor suppression. The gene discussed is RUNX2; the disease is neoplasm.