We transiently co-transfected CRC cells with five PEPT1 promoter constructs based on the pGL3 luciferase reporter (Fig. 5A) and siRNAs targeting the histone acetyltransferases CBP/P300, which are specifically required for H3K18Ac and H3K27Ac33,34. This evidence concerns the gene SLC15A1 and colorectal carcinoma.