Synflorix® contains protein D from non-typeable Haemophilus influenzae (NTHi) that acts as a carrier for pneumococcal serotypes, which may offer broader protection against acute otitis media (AOM) [40] as NTHi infection is one of the most common causes of, alongside pneumococcal infection, of AOM in children [41]. This evidence concerns the gene DHRS2 and infectious otitis media.