These findings fit well with human genetic data implicating both α-synuclein and LRRK2 in the pathogenesis of Parkinson’s disease, as well as with the neuropathological finding of frequent Lewy pathology (aggregated α-synuclein) in the brains of Parkinson’s disease patients with mutations in LRRK2 [57, 58]. Here, LRRK2 is linked to Parkinson disease.