We have previously demonstrated that altering Lrrk levels does not influence the toxicity of mutant SCA3, a polyglutamine-expanded protein linked to spinocerebellar ataxia type 3 (Machado-Joseph disease), in an unrelated Drosophila model of age-dependent neurodegeneration [29]. Here, ATXN3 is linked to Spinocerebellar ataxia type 3.