In this research, we found that downregulation of TUG1 notably diminished the protein levels of β-catenin, c-Myc, Bcl-2 and upregulated the expression of E-cadherin in CRC cells, whereas downregulation of miR-542-3p or overexpression of TRIB2 reversed the effects. Here, TUG1 is linked to colorectal carcinoma.