Besides, Overexpression of APP in HGLO group was detected in 15 cancer types and suggested potential resistance to 33 types of drugs, including Teniposide, Mitoxantrone, Oxaliplatin, and Irinotecan, all of the which target DNA replication (r = 0.434, r = 0.425, r = 0.416, and r = 0.366, respectively). The gene discussed is APP; the disease is cancer.