For example, the expression of ASAP2, which has been identified as a biomarker for several types of tumor, is up-regulated in HGLO in 16 cancer types and positively correlated with the resistance to DNA topoisomerases inhibitor Topotecan (r = 0.40) and DNA synthesis inhibitor Gemcitabine (r = 0.34). The gene discussed is ASAP2; the disease is neoplasm.