In genome-wide association studies, TNFAIP3 polymorphisms were found to be associated with a variety of autoimmune [15] and autoinflammatory diseases [16], such as systemic lupus erythematosus [17], Sjögren’s syndrome, Crohn’s disease, rheumatoid arthritis, Still’s disease in adults, juvenile idiopathic arthritis, psoriatic arthritis, Hashimoto’s thyroiditis [18], autoimmune lymphoproliferative syndrome [19], type 1 diabetes, and psoriasis. This evidence concerns the gene TNFAIP3 and systemic lupus erythematosus.