G9a knockout MEF cells exposed to interferon show specific overinduction of Toll-like receptors 2 and 4, their intracellular adaptors MYD88 and LCK [25], as well as STX8, a protein involved in lytic granule trafficking that may be required to engulf pathogens after infection [26] and during cytotoxic T-cell responses [27]. The gene discussed is STX8; the disease is infection.