Our findings demonstrated that vitamin and mineral supplementation, magnesium, zinc, selenium, calcium, vitamin D and E (alone or in combination), significantly improved glycemic control, attenuated inflammation and oxidative stress in women with GDM through decreasing serum FPG, insulin, HOMA-IR, HOMA-B, hs-CRP and MDA levels, and increasing TAC levels. The gene discussed is INS; the disease is gestational diabetes.