These variables were: age, comorbidities (hypertension, myocardiopathy, dyslipidemia, obesity), excessive tobacco and alcohol consumption, anticoagulant or use of platelet aggregation inhibitors, mucosal bleeding, hematuria and/or presence of blood in stools, skin rash, clinical liquid accumulation, abdominal pain, simultaneous hematocrit increase and platelet count drop, platelets < 30 × 109/L, ALT and/or AST > 10 N. Here, GPT is linked to obesity due to melanocortin 4 receptor deficiency.