NPPB and acute kidney injury: 5.There were also significant differences in the comorbidities (septic shock, AKI, ARF, SIMD) after entering ICU occurred in the two groups of patients (BNP on d3 < 681.5pg/ml or BNP on d3 > 681.5pg/ml) (P < 0.05), which indicated that the higher the BNP of the patients, the more likely to merge with shock, AKI, ARF or SIMD.