Heart-brain axis has a greater role in the procession of cognitive impairment and dementia [6–8], available population-based evidence reported suboptimal cardiac function or abnormally elevated cardiac biomarkers, such as N-terminal pro-B-type natriuretic peptide (NT-proBNP) or high-sensitivity cardiac Troponin T (hs-cTnT), were associated with worse cognitive performance [9–13], suggesting cardiac biomarkers may be used to identify individuals at higher risk of cognitive impairment. Here, NPPB is linked to Cognitive impairment.