STK11 and diabetic kidney disease: Recently, a study demonstrated that L-aspartate supplementation could ameliorate diabetic kidney disease in mice.47 In mechanism, a latest study done by Jiang et al revealed that L-aspartate can directly interact with phosphorylated LKB1 leading to an activation of LKB1-AMPK axis in cells.37 Consistently, our study also found L-aspartate treatment activated LKB1-AMPK axis in hepatocyte and intestinal cells, enhanced lipid oxidation and inhibited oxidative stress and its induced cell injury, thus ameliorating MAFLD.