Univariate and multivariate Cox regression analyses revealed that higher pathologic T stage, metastasis and high immunostaining intensity of NUPR1 were unfavorable prognostic factors in ccRCC patients, (OS, HR = 2.263, 95% CI = 1.061– 4.827, p = 0.035, Table 2; DFS, HR = 2.031, 95% CI = 1.021– 4.040, p = 0.043, Table 3). This evidence concerns the gene NUPR1 and nonpapillary renal cell carcinoma.