Genomewide gene expression profiling provided further evidence for central roles of MTSS1 in normal and malignant myelopoiesis: 967 genes whose expression was significantly altered upon knockout of MTSS1 in a human AML cell line were enriched for known targets of myeloid and/or leukemia-associated transcription factors, for example, MYC, RUNX1, CREB1, GATA2, STAT3, MEIS1, CEBPA, SPI1 (alias PU.1), and MECOM [94]. This evidence concerns the gene CREB1 and acute myeloid leukemia.