Interestingly, among the RAMP genes, only RAMP1 mRNA was detectable in all analyzed specimens, whereas RAMP2 and RAMP3 transcripts were measurable only in 0 and 25% of the samples, respectively, suggesting that CALCRL acts mainly as a CGRP, rather than as an ADM, receptor in AML [74]. The gene discussed is RAMP3; the disease is acute myeloid leukemia.