HB‐EGF was negatively associated with the survival rate of the clinical samples (Fig. 5E and Fig. S5A–C), and the expression of HB‐EGF induced a lower DSS (P = 0.036), PFI (P = 0.046), and OS (P = 0.013) of HCC. The gene discussed is HBEGF; the disease is hepatocellular carcinoma.