In contrast, the expression of MeCP2, HOXD3, HB‐EGF, EGFR, p‐MEK, and p‐ERK1/2 was inhibited in shMeCP2‐transfected HCCs (Fig. 2J), which strongly suggested that MeCP2 plays an essential role in tumor progression. Here, HBEGF is linked to neoplasm.