It is worth noting that the mutual regulation between NF‐κB and miRNA forms a positive feedback loop to further enhance the activity of NF‐κB and accelerate the IDD process; for example, the expression levels of inflammatory factors TNF‐α and IL‐1β mRNA are increased in the degenerated NP tissue, and this inflammatory environment promotes miR‐640 expression through the NF‐κB signalling pathway. Here, TNF is linked to intervertebral disk degenerative disorder.