According to the results, the core targets might affect signaling pathways including the Rap1 signaling pathway, MAPK signaling pathway, EGFR tyrosine kinase inhibitor resistance and AGE-RAGE signaling pathway in diabetic complications, which predicts that SGLT2 inhibitors might be effective for treatment of DM with HF by regulating the aforementioned signaling pathways. The gene discussed is SLC5A2; the disease is diabetes mellitus.