The statistical analysis was performed on each target gene to obtain the top targets with the number of adjacent genes  ≥ 10 (shown in Fig. 7), revealing that SRC, MAPK1, NARS, MAPK3 and EGFR are the top five hub targets, which may be the key targets for SGLT2 inhibitors in the treatment of DM with HF. Here, SLC5A2 is linked to diabetes mellitus.