In contrast, as seen by detection of the 43, 41, and 18 kDa cleavage products of caspase-8, 35 kDa cleavage product of caspase-9, and 17 kDa cleavage product of caspase-3, there was strong activation of the respective caspases in Mel-HO cells after infection with AdV-TRAIL and induction of TRAIL expression by Dox (Fig. 5C, Supplementary Figure S1). This evidence concerns the gene CASP3 and infection.