MCL1 and melanoma: Calculation of the average relative increase of apoptotic cells mediated by Mcl-1 silencing in AdV-TRAIL-infected melanoma cells with Dox-induced TRAIL expression 48 h after application of the virus revealed that co-silencing of Mcl-1 increased the percentage of apoptotic cells by 61% in MeWo but only by 31% in Mel-HO cells compared to the sole AdV-TRAIL treatment.